Functional Database for Deep Brain Neurosurgery Planning

RESEARCH INTERESTS

• Engineering for diagnostic and surgical procedures in clinical environment

My project involves the development of a visualization and navigation system and its application in pre-operative planning and intra-operative guidance of stereotactic deep-brain neurosurgical procedures for the treatment of Parkinson’s disease, chronic pain, and essential tremor. This system incorporates a variety of standardized functional and anatomical information, and is capable of non-rigid registration, interactive manipulation, and processing of clinical image data. The integration of a digitized and segmented brain atlas, an electrophysiological database, and collections of final surgical targets of previous patients facilitates the delineation of surgical targets, surrounding structures, as well as functional borders.

 

KEY QUESTIONS

• What is the most efficient surgical target and trajectory identification approach for deep brain stimulation (DBS) procedures?
• Can the use of our neurosurgical navigation system in the surgical target and trajectory planning diminish the surgical procedure-elicited intracranial hemorrhage, brain tissue damage, and other related complications by reducing the number of exploratory instruments and the duration of the surgical process?

 

SELECTED PUBLICATIONS

Book Chapters

1. TM Peters, KW Finnis, T Guo, and AG Parrent. “Chapter 11 – Neurosurgical Applications”. In: Image-Guided Intervention Principles and Applications, TM Peters and K Cleary (Eds), Springer-Verlag, Berlin, Heidelberg: In Press, 2007.

Refereed Journal Publications

1. T Guo, AG Parrent, and TM Peters. Probabilistic Functional Map based Automatic Surgical Target and Trajectory Planning for Deep Brain Stimulation (DBS). Computer Aided Surgery, vol. **(*), pp. ***-***, 2008. (Invited)

2. T Guo, AG Parrent, and TM Peters. Surgical Targeting Accuracy Analysis of Six Methods for Subthalamic Nucleus Deep Brain Stimulation. Computer Aided Surgery, vol. 12(6), pp. 325-334, 2007.

3. T Guo, KW Finnis, AG Parrent, and TM Peters. Visualization and Navigation System Development and Application for Stereotactic Deep-Brain Neurosurgeries. Computer Aided Surgery, vol. 11(5), pp. 231-239, 2006.

 

CURRICULUM VITAE