Research Spotlight

  • Research Award, Canadian Hypertension Society
  • Dean's Honour List, University of Toronto Executive MBA, 1991
  • Stroke Recovery Association Clifford J. Goodall Award of Merit, 1998
  • Fellow of the Canadian Academy of Health Sciences, 2008
  • Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology, October 25, 2015
  • PSIF Clinical Research Award
  • Naylor Award for Best Thesis in Health Services Research
  • CIHR Knowledge Synthesis Award
  • CSCI/CIHR Award for Excellence in Resident Research
  • PSI Award for Excellence in Resident Research

Address & Contact Information

Stroke Prevention & Atherosclerosis Research Centre (SPARC)
Siebens-Drake Building
Robarts Research Institute
1400 Western Road
London, Ontario N6G 2V4
Phone: 519-931-5731
Fax: 519-931-5737
Email: sparc@robarts.ca

Welcome to SPARC

We are a clinical research unit of the Robarts Research Institute, Western University. Our primary mission is stroke prevention. Atherosclerosis is the underlying process that causes most heart attacks and strokes. We have developed a way to measure atherosclerosis by measuring the "Total Plaque Area" (TPA) in arteries using 2-D and 3-D ultrasound. Our ability to measure TPA enables us to measure the change in TPA over time and enables us to focus our clinical research in 4 specific areas.

  1. Developing treatments that treat arteries instead of just stroke risk factors.
  2. Identifying new genetic risk factors that cause atherosclerosis.
  3. Testing the effectiveness of new treatments for atherosclerosis.
  4. Replacing intestinal bacteria to treat arteries.
Metabolic products of the intestinal microbiome and extremes of atherosclerosis. Atherosclerosis
Bogiatzi C, Gloor G, Allen-Vercoe E, ...Spence JD. Metabolic products of the intestinal microbiome and extremes of atherosclerosis. Atherosclerosis....
Pioglitazone Therapy in Patients With Stroke and Prediabetes
Spence JD, Viscoli CM, Inzucchi SE, et al. Pioglitazone Therapy in Patients With Stroke and Prediabetes. JAMA Neurol. 2019 (The heading could be...
Dr. Spence invited co-investigator of the China Stroke Primary Prevention Trial 2
Dr. Spence has been invited to be a co-investigator and member of the steering committee of the China Stroke Primary Prevention Trial 2; a trial of...

Henry Stewart Talks

Dr. David Spence has recently contributed 3 talks to The Biomedical and Life Sciences Collection of the Henry Stewart Talk series. The on-line videos can be reached from Dr. J. David Spence's " Internet Citations page "

SPARC - Stroke Prevention Research
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